Conoidin A

Research use only, not for human use.

Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties.

Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. It covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. It also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII). Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease.

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Microbiology/Virology

Parasite

Parasite

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18080-67-6

348.0

C10H8Br2N2O2

>98% (HPLC)

DMSO:14.29 mg/mL?(41.06 mM;?Need ultrasonic)

[O-][N+]1=C(CBr)C(CBr)=[N+]([O-])C2=CC=CC=C21

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(-20℃)

With Ice Pack

≥ 2 years